Why Combining Proteins and DNA Can Help with Unexplained Disorders and Predict Health Risks?

Using proteomics (studying 7000 proteins in your blood) together with whole genome sequencing (WGS) (looking at all your DNA) can be really helpful in finding the causes of unexplained health problems and predicting future risks. Here’s why:

WGS Finds the Genetic Causes, Proteomics Shows the Effects

• Whole genome sequencing, or WGS, looks at the DNA to find changes that could cause health issues. But sometimes, genetic changes don’t directly cause clear problems.

• Proteomics (analyzing 7000 proteins) looks at the proteins in the body, which do most of the work in our cells. These proteins are often affected by genetic changes. By combining both, we can see how genetics affect the body in real ways.

A Complete View of Health

• WGS tells us about the genetic factors behind health problems, while proteomics shows us how those genetic changes impact the body. This gives doctors a fuller picture of why someone is sick.

Better Diagnosis for Unclear Conditions

• Some health problems don’t have obvious causes or clear symptoms. Proteomics can help uncover hidden changes in the body caused by genetic mutations, leading to a better diagnosis, especially when other tests haven’t worked.

Predicting Health Risks

• Combining WGS and proteomics helps us understand how genetic factors affect proteins in the body. This can help doctors predict if someone is more likely to develop certain health problems, like heart disease or cancer, in the future.

Personalized Treatments

• With both WGS and proteomics, doctors can recommend treatments that are more specific to the individual’s genetic and protein changes, making treatments more effective.

Personalized Nutrition, Exercise and Weight Loss

Your DNA can show how your body reacts to food, exercise, and weight loss. Here’s how:

Better Diet

• DNA helps figure out which foods work best for you, like whether you burn fat or carbs better.

Personalized Exercise

• DNA shows what type of exercise is best for you, like running or strength training.

Easier Weight Loss

• DNA can explain why you might find it harder to lose weight, so you can adjust your plan.

Better Health

• DNA helps you make healthier choices for more energy and overall well-being.

Faster Results

• When your plan fits your DNA, you’ll see better results and stay on track.

In short, combining proteomics and whole genome sequencing helps doctors better understand unexplained health issues, predict risks, and create more personalized treatments for patients.

Learn More

Your DNA

Common diseases, like cancer and heart problems, are the leading causes of early death in adults aged 50-75.

• Many of these conditions have no symptoms at first and are often discovered during routine checkups.

• While lifestyle and environmental factors play a role, many of these diseases are also linked to genetics.

These genetic causes are often difficult to diagnose with regular tests because the symptoms overlap with other conditions.

• Some people with certain gene mutations develop the disease, while others don't.

Testing for genetic risks, whether caused by one gene (monogenic) or multiple genes (polygenic), can help explain symptoms like pain, headaches, heart palpitations, or numbness.

• Whole genome sequencing, along with a thorough clinical assessment, can offer better insight into these conditions.

7000 Proteins

Plus, 7000-blood protein testing helps predict the risk of certain diseases by analyzing proteins in the blood. It can estimate the chances of a heart attack, stroke, dementia and lung cancer within a few years. The test looks at proteins, and also combines genetic factors to better predict risks.

Clinical Deep Phenotyping

Deep Phenotyping is the process of thoroughly assessing unexplained health issues.

• Rainbow’s collaborating doctors look at symptoms, family history, and test results to better understand the full picture before doing genetic tests.

• This detailed review helps increase the chances of finding the genetic cause of the illness.

1. Your DNA Health

This test looks at over 20,000 genes and 3 billion base pairs in your DNA to check your risk of developing genetic disorders, including certain cancers, heart diseases, and other rare conditions.

• There are over 8,000 known genetic disorders. For example, about 5% of breast and colon cancers are caused by genetic factors, and 1 in 500 people have a gene that can cause heart disease.

• The test finds genetic changes linked to these disorders. If you have a genetic mutation, it doesn’t mean you will definitely get the disease, but it helps your doctor create a plan to manage your risk.

• Includes

  • Cancers

  • Cardiovascular Disorders

  • Diabetes and Fatty Liver

  • Sleep Disorders

  • Hearing and Eye Disorders

  • Skeletal and Bone Disorders

  • Immune System Disorders

  • Skin Abnormality

  • Auto-inflammatory Disorders

  • Behavioral Abnormality

  • Dementia and Alzheimer Disease

2. Your Protein Health

7000 blood proteins determine if you may have a heart attack, stroke, dementia or lung cancer within the next few years

1. Stroke & Heart Attack: Predict your risk of heart attack, stroke, or heart failure in the next 4 years. It also estimates the chance of a second heart attack.

2. Lung Cancer: Predict your risk of lung cancer in the next 5 years, considering both your genetics and lifestyle, like smoking.

3. Dementia: Predict your risk of dementia or other brain diseases over the next 4 to 20 years based on your genes and other risk factors.

4. Fatty Liver and Blood Sugar: This test checks if you have fatty liver or blood sugar problems, which can increase your risk of heart disease and diabetes.

3. Your Reproductive Health

This test checks over 20,000 genes to find genetic mutations that could be passed on to your children and cause inherited conditions.

• Carrier screening helps find out if you carry a mutation that could lead to a serious condition in your baby.

• There are over 1,300 known conditions, many of which are rare and not picked up by regular prenatal tests.

• For a child to have these conditions, both parents need to carry the same mutation. If both parents are carriers, there’s a 1 in 4 chance their child could inherit the condition.

Unlike other tests that look at fewer genes or focus mainly on people of European descent, this test looks at over 20,000 genes, which helps catch mutations that are specific to Asian populations.

4. Your Drug Response to over 185 Medications

Taking the wrong medication or the wrong dose can lead to delayed treatment, re-hospitalization, harmful side effects, and even death.

• Studies show that many drugs only work effectively for 50-75% of people. Adverse drug reactions are the 4th leading cause of death in the U.S.

This test helps reduce harmful reactions, make drugs work better, and prevent bad interactions between medications.

• Comprehensive. Includes 22+ genes, 350+ common medications, and 28 medical conditions

• Credible. Uses clinical evidence curated with Mayo Clinic from FDA label information, Clinical Pharmacogenetics Implementation Consortium, and other professional guidelines and scientific studies

5. Diagnosis of Your Symptoms

If you have a family history or symptoms of a condition that could be genetic, your doctor may recommend this test.

6. Your Genetic Counseling Session

Even if you have genetic mutations or they run in your family, it doesn't always mean you'll develop a genetic disorder. Speaking with a certified genetic counselor is important to understand what carrying certain genetic variants means.

Genetic Counseling for Patients.  Rainbow Genomics provides a variety of bilingual-genetic counseling services to our patients, in Mandarin, Cantonese and English.

Physician Consultation:  Peer-to-Peer Discussions.  Rainbow Genomics also delivers two levels of support for ordering physicians to enhance their ability to provide the best care to their patients.

Is This Test Right For You?

The Rainbow Adult Screening Whole Genome Sequencing test might be right for you if:

• You have unexplained health problems that haven't been diagnosed

• You're healthy and want to know your risk for certain disorders like hereditary cancers or heart disease

• You're planning to have children and want to understand your risk of passing on a genetic mutation

• You want to know how you might respond to over 185 different medications

This test is not for children

If your child has symptoms that might be linked to a genetic disorder, you should consider the Rainbow Pedi 1000™ Whole Genome Sequencing Test

We provide free referrals to physicians with substantial clinical genetic experience for pre- and post-test consultation.