Pharmacogenomic Test

Psycho-Pharmacogenomic Testing

  • Cover 185 medications

  • Tests 100 gene variations in 27 genes

  • Includes copy number variations

Introduction

Pharmacogenomic testing looks at how your genes affect how you respond to medications.

  • It can help your doctor choose the right medications and dosages for you, making them more effective.

When you take a medication, many factors like your gender, weight, age, diet, other medications, and health conditions play a role in how your body reacts.

  • Your genes also have a big impact, influencing up to 95% of your response to medication.

  • Since everyone has unique genetic variations, they can determine how quickly your body processes medications.

Depending on your genes, your body might break down a medication too fast or too slow.

  • If you break it down too slowly, you could get too much of the drug, causing harmful side effects.

  • If you break it down too quickly, the drug might not work as it should.

Rainbow Pharmacogenomic test

Genetic factors can explain up to 95% of why a medication works differently for each person.

Your genes play a huge role in how well a drug will work - or not work - for you.

  • Studies show that more than 90% of people have genetic traits that affect how they respond to medications.

  • The Rainbow Pharmacogenomic test helps identify these genetic variations and predicts how you might react to different drugs, giving doctors personalized recommendations for your treatment.

This test is a cost-effective way to understand how your genes affect your response to medications.

  • We analyze your genetic information and provide a report to help doctors make more informed and effective decisions about your prescriptions.

  • The test covers 100 genetic markers, 27 genes, over 185 medications, and 28 health conditions.

Rainbow Psycho-Pharmacogenomic(TM) Testing Services

Enable physicians to improve outcomes of treatment-resistant or treatment-intolerant patients

  • Many patients don’t respond well to their first treatment, especially for conditions like depression, bipolar disorder, and schizophrenia, where 30%-50% of people don't respond to the first antidepressant they try.

  • This can lead to more serious problems, including suicidal thoughts or aggressive behavior if psychosis isn't properly treated.

Psychiatrists can use both experience and genetic information about how drugs work to make better decisions when choosing medications. This helps avoid the guesswork often involved in treating mental health conditions.

Integrative Psycho-Pharmacogenomics Strategy

  • When standard treatment options don’t work, doctors often face a challenge.

  • There are few guidelines for situations where common medications fail, and the process of trying different drugs to find the right one can be slow and frustrating.

Pharmacogenomic testing helps solve this by looking at how a person’s genes affect how they process medications.

  • This can tell doctors which drugs will work best, which might cause problems, and which should be avoided altogether.

  • It reduces the trial-and-error process, allowing for faster, more effective treatment with fewer side effects.

Test Descriptions

Reduce “missed results” - False Negative Results

  • Our test checks 100 genetic versions (alleles) in 27 genes to help reduce the chance of missed results, especially for people of Asian, Caucasian, or mixed races.

  • These alleles are found at different rates in different populations, and our test is designed to catch these differences, including rare variations (CNVs), which most other tests miss.

  • This helps provide a more accurate report on how your body might respond to over 180 medications

Real-world example

Example 1: How CYP2C19 Gene Variations Affect Antidepressant Choices

Citalopram and sertraline are common antidepressants used in both children and adults.

  • However, Asian patients are more likely to have certain gene variations (CYP2C19 *2 and *3) that make it harder for their bodies to process these medications, leading to higher drug levels and potential side effects.

  • To help avoid this, doctors are advised to reduce the dose of these medications by 50%, or they may choose a different drug that is not affected by these gene variations.

The Rainbow test checks for these gene variations and helps determine if a person is a slow metabolizer of these drugs.

It also recommends alternative medications, like escitalopram, which the body can process at normal levels.

  • This information helps doctors quickly decide on the best treatment, either by adjusting the dose or choosing a more suitable medication.

Example 2: Why Testing CYP2D6 Gene Variations is Important?

he CYP2D6 enzyme helps your body process about 25% of commonly used medications, like antidepressants, painkillers, psychiatric drugs, and others.

  • Differences in the CYP2D6 gene can cause people to have side effects from these medications.

  • The Rainbow test checks 42 different versions of this gene to help predict how you might react to these drugs.

test Description

  • During the office visit, your physician will also collect your DNA sample through a simple cheek swab.

  • The sample will be sent to a U.S. CAP-accredited and CLIA-certified clinical testing laboratory.

  • The clinical team will perform the testing, analysis and issue a clinical test report.

Is This Test Right For You?

Your test results can be useful for making better medication choices throughout your life.

While this test can help anyone, it’s especially helpful for people with the following concerns:

  • Medications that cause side effects

  • Multiple prescriptions

  • Medications that aren’t working

  • Multiple medications are available and you don’t know which one to use

  • You are diagnosed with cancer and you do not have time to try multiple chemotherapy medications

References

Physician Order Required